HMGB1 as a drug target in staphylococcal pneumonia
نویسندگان
چکیده
منابع مشابه
HMGB1 as a drug target in staphylococcal pneumonia
High mobility group box (HMGB)1 is a small DNA-binding protein. In the nucleus, HMGB1 plays a role in gene expression and DNA replication. When it is released or secreted into the extracellular milieu, HMGB1 functions as a pro-inflammatory cytokine-like mediator. Recently reported data support the view that treatment with a neutralizing anti-HMGB1 antibody ameliorated pulmonary damage in a muri...
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متن کاملStaphylococcal Pneumonia
STAPHYLOCOCCAI pneumonia is a well-recognised complication of epidemic influenza. Chickering and Park (1919) described 155 cases, and more recently 66 cases were recorded by Finland, Peterson, and Strauss (1942). Smaller series have also been reported, and both the virus influenza A and the staphylococcus were isolated from patients by Scadding (1937) and Michael (1942). It can also occur as a ...
متن کاملCommunity-acquired staphylococcal pneumonia.
OBJECTIVE Staphylococcal pneumonia typically presents high rates of morbidity and mortality. It typically occurs in cases of influenza (airborne transmission) or during episodes of bacteremia (blood-borne transmission). METHODS A retrospective and descriptive study was conducted in patients admitted to our hospital between January of 1992 and December of 2003. All of he patients included had ...
متن کاملReport on a Case of Staphylococcal Pneumonia with Staphylococcal Septicæmia
PERSONAL HISTORY. IHE patient, a female, aged 10 years, weighing 5 st. 6 lb., height 4 ft. 10 in., has a congenital heart lesion, recognised since birth and described below. No disease in infancy. Chicken-pox. Measles and lobar pneumonia (consolidation both sides)' all in sixth year. Lobar pneumonia again at seven years. Influenza age 8; nil since, apart from a mild catarrhal cold with no tempe...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2014
ISSN: 1364-8535
DOI: 10.1186/cc13810